|
两个独立的研究小组10日说，他们已找到与高血压有关的13个基因，其中多数人们以前从未怀疑与高血压有关。 两项研究已于当天发表在英国《自然·遗传学》杂志网络版上，它们分别通过对近3万人和近13万人的全基因组分析各自找到了8个与高血压有关的基因，其中3个基因完全相同。 研究人员指出，这些基因中，一些影响人体中的钙传输，一些影响血管舒张，还有一些会导致自体免疫性疾病，但多数以前从未被列入高血压“疑凶名单”。 其中一项研究的第一作者、美国马萨诸塞综合医院的克里斯托弗·牛顿－泽说，新发现是研究高血压“一大进步”，它扩大了人们对高血压发病机理的认知范围，可有助于寻找治疗甚至预防高血压的药物目标。 另一项研究的第一作者、美国约翰斯·霍普金斯大学的阿拉温达·查克拉瓦蒂则指出，他们发现的基因中，单独来看，每一个对高血压的影响并不大，但综合起来“影响显著”。 推荐原始出处： Nature Genetics 10 May 2009 | doi:10.1038/ng.361 Genome-wide association study identifies eight loci associated with blood pressure Christopher Newton-Cheh1,2,3,94, Toby Johnson4,5,6,94, Vesela Gateva7,94, Martin D Tobin8,94, Murielle Bochud5, Lachlan Coin9, Samer S Najjar10, Jing Hua Zhao11,12, Simon C Heath13, Susana Eyheramendy14,15, Konstantinos Papadakis16, Benjamin F Voight1,3, Laura J Scott7, Feng Zhang17, Martin Farrall18,19, Toshiko Tanaka20,21, Chris Wallace22,23,24, John C Chambers9, Kay-Tee Khaw12,25, Peter Nilsson26, Pim van der Harst27, Silvia Polidoro28, Diederick E Grobbee29, N Charlotte Onland-Moret29,30, Michiel L Bots29, Louise V Wain8, Katherine S Elliott19, Alexander Teumer31, Jian'an Luan11, Gavin Lucas32, Johanna Kuusisto33, Paul R Burton8, David Hadley16, Wendy L McArdle34, Wellcome Trust Case Control Consortium93, Morris Brown35, Anna Dominiczak36, Stephen J Newhouse22,23, Nilesh J Samani37, John Webster38, Eleftheria Zeggini19,39, Jacques S Beckmann4,40, Sven Bergmann4,6, Noha Lim41, Kijoung Song41, Peter Vollenweider42, Gerard Waeber42, Dawn M Waterworth41, Xin Yuan41, Leif Groop43,44, Marju Orho-Melander26, Alessandra Allione28, Alessandra Di Gregorio28,45, Simonetta Guarrera28, Salvatore Panico46, Fulvio Ricceri28, Valeria Romanazzi28,45, Carlotta Sacerdote47, Paolo Vineis9,28, Inês Barroso12,39, Manjinder S Sandhu11,12,25, Robert N Luben12,25, Gabriel J Crawford3, Pekka Jousilahti48, Markus Perola48,49, Michael Boehnke7, Lori L Bonnycastle50, Francis S Collins50, Anne U Jackson7, Karen L Mohlke51, Heather M Stringham7, Timo T Valle52, Cristen J Willer7, Richard N Bergman53, Mario A Morken50, Angela D?ring15, Christian Gieger15, Thomas Illig15, Thomas Meitinger54,55, Elin Org56, Arne Pfeufer54,55, H Erich Wichmann15,57, Sekar Kathiresan1,2,3, Jaume Marrugat32, Christopher J O'Donnell58,59, Stephen M Schwartz60,61, David S Siscovick60,61, Isaac Subirana32,62, Nelson B Freimer63, Anna-Liisa Hartikainen64, Mark I McCarthy19,65,66, Paul F O'Reilly9, Leena Peltonen39,49, Anneli Pouta64,67, Paul E de Jong68, Harold Snieder69, Wiek H van Gilst27, Robert Clarke70, Anuj Goel18,19, Anders Hamsten71, John F Peden18,19, Udo Seedorf72, Ann-Christine Syv?nen73, Giovanni Tognoni74, Edward G Lakatta10, Serena Sanna75, Paul Scheet76, David Schlessinger77, Angelo Scuteri78, Marcus D?rr79, Florian Ernst31, Stephan B Felix79, Georg Homuth31, Roberto Lorbeer80, Thorsten Reffelmann79, Rainer Rettig81, Uwe V?lker31, Pilar Galan82, Ivo G Gut13, Serge Hercberg82, G Mark Lathrop13, Diana Zelenika13, Panos Deloukas12,39, Nicole Soranzo17,39, Frances M Williams17, Guangju Zhai17, Veikko Salomaa48, Markku Laakso33, Roberto Elosua32,62, Nita G Forouhi11, Henry V?lzke80, Cuno S Uiterwaal29, Yvonne T van der Schouw29, Mattijs E Numans29, Giuseppe Matullo28,45, Gerjan Navis68, G?ran Berglund26, Sheila A Bingham12,83, Jaspal S Kooner84, John M Connell36, Stefania Bandinelli85, Luigi Ferrucci21, Hugh Watkins18,19, Tim D Spector17, Jaakko Tuomilehto52,86,87, David Altshuler1,3,88,89, David P Strachan16, Maris Laan56, Pierre Meneton90, Nicholas J Wareham11,12, Manuela Uda75, Marjo-Riitta Jarvelin9,67,91, Vincent Mooser41, Olle Melander26, Ruth JF Loos11,12, Paul Elliott9,94, Gon?alo R Abecasis92,94, Mark Caulfield22,23,94 & Patricia B Munroe22,23,94 Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N less than or equal to 71,225 European ancestry, N less than or equal to 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 times 10-24), CYP1A2 (P = 1 times 10-23), FGF5 (P = 1 times 10-21), SH2B3 (P = 3 times 10-18), MTHFR (P = 2 times 10-13), c10orf107 (P = 1 times 10-9), ZNF652 (P = 5 times 10-9) and PLCD3 (P = 1 times 10-8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. (责任编辑：Doctor001) |
